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E-catalogue (Momordica Charantia Extract) Page of 3

Catalogue ID: C57


Momordica Charantia Extract



Botanical: Momordica charantia
Family: Cucurbitaceae
Momodica Charantia is commonly known as bitter melon. Its other names are Bitter Gaurd, Balsam Pear, Karela and Ampalaya. It tastes very bitter, like a light green, fat and pointed cucumber with a prominently warty skin. It has bright red seeds inside. These seeds must be removed before usage. It is utilized in food as well as medicine. Although the seeds, leaves and vine of bitter melon have all been used, the fruit is the safest and most prevalent part of the plant used medicinally.
Bitter melon is a tropical plant currently distributed across the globe. The probable place of origin is either China or India. The immature fruits are a good source of vitamin C and provide some vitamin A, phosphorus, and iron. It is a fast growing, trailing or climbing vine with thin stems and tendrils.


APPLICATIONS


Some groups of constituents in bitter melon have been reported to have hypoglycemic or other actions of potential benefit in diabetes mellitus. This includes a mixture of steroid saponin known as Charantin, insulin-like peptides and alkaloids. It is a very popular plant that can prevent cancer, diabetes and many infectious diseases. It is a powerful weapon against human immunodeficiency virus (HIV).
Therapeutic Actions:

  • Antibiotic

  • Antitumor activity - due to the constituents lutein and lycopene

  • Decreases cGMP:cAMP ratio

  • Inhibits corticotropin-induced lipolysis creating an insulin-sparing action

  • Hypotensive

  • Lowers blood glucose


Scientific Research




  • Momorcharin proteins purified from the seeds of bitter melon have shown immunosuppressive activity.

[Leung SO, Yeung HW, Leung KN “The immunosuppressive activities of two abortifacient proteins isolated from the seeds of bitter melon (Momordica charantia)” Immunopharmacology, 13:159-171, 1987.]


  • MAP30 protein isolated from bitter melon show inhibition of HIV by inactivation of viral DNA. It also shows anti-cancer activity.

[Lee-Huang S, Huang PL, Chen HC, Huang PL, Bourinbaiar A, Huang HI, Kung HF “Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon.” Gene, 161:151-156, 1996.]


  • Investigations were carried out to evaluate the effect of Momordica charantia on the glucose tolerance of maturity onset diabetic patients. The fruit juice of M. charantia was found to significantly improve the glucose tolerance of 73% of the patients investigated.

[Welihinda J, Karunanaya E, Sheriff MHB, Jayasinghe K. “Effect of Momardica charantia on the glucose tolerance in maturity onset diabetes.” J Ethnopharm, 17:277–82, 1986.]


  • Using five experimental models, the blood sugar lowering efficacy of eight plants of Cucurbitaceae family has been assessed. The ethanolic extract of Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when administered in 250 mg/kg dose, orally to rats failed to lower blood sugar or to depress the peak value, after glucose load. However, ethanolic extract of Momordica charantia Linn plant and Coccinia indica Whit and Arn root significantly lowered blood sugar in fasted model and depressed the peak value in glucose loaded model.

[Chandrasekar B, Mukherjee B, Mukherjee SK “Blood sugar lowering potentiality of selected Cucurbitaceae plants of Indian origin.” Indian J Med Res, 90:300-305, 1989.]

SPECIFICATION


Product name:
Bitter Melon P.E.

Botanical name:
Mormordia Charantia

Part used:
Fruits



Items

Standard


Appearance:
Light yellow powder

Taste:
Bitter taste

Sieve analysis:
Pass 60 mesh

Moisture:
<5.0%

Extract ratio:
25:1

Extract solvents:
Alcohol & Water

Charantin:
>3%

pH:

5.5~6.5

Ash:

<5%

Heavy Metals:

<20ppm

Solvents Residue:

<0.05%




Microbiological

Total Bacteria:

<1000cfu/g

E.Coli.:

Absent

Salmonella:

Absent

Mold:

<50cfu/g

Yeast:

<50cfu/g

Storage: Store in well-closed container, cool & dry area. Keep away from strong, direct light.



Shelf life: Typically 24 months when stored properly.



Zhen Hua Trading Limited

Room 2003, 20/F, C.C. Wu Building, 302-308 Hennessy Road, Wanchai, HK

Tel : (852) 2527 1125

Fax : (852) 2529 0470

Websites: www.zhenhua.com.hk

E-mail : herbs@zhenhua.com.hk





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